What is SAM-e (S-Adenosyl methionine)

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SAM-e is a chemical compound that is made naturally within the body and synthetically in laboratories. Unlike most compounds, it cannot be found in food and hence, if there is a deficiency, SAM-e must be supplemented.

SAM-e has shown to be a highly effective treatment for osteoarthritis pain. Various studies have shown that taking 600-800mg daily has the same pain relieving effect as NSAID painkillers. It should be noted that being SAM-e takes longer to act than common NSAIDs, however, it has far less side effects.

It is also an effective treatment for depression. Taking 400-1600mg of SAM-e daily has shown to be just as effective as over the counter anti-depressants in relieving symptoms.

There is also some evidence that suggests that SAM-e may be an effective treatment for the symptoms of schizophrenia, such as, aggression and depression, however, the evidence is non-conclusive and requires further extensive research.

Other uses of SAM-e, although not as extensively studied, include: treating liver damage, liver cirrhosis, fatty liver disease, fibromyalgia, treatment of ADHD symptoms, improving bile flow and relieving migraines.


Although there are no definite doses, typical doses consist of:

      • 400-1600mg daily for depression
      • 600-800mg daily for osteoarthritis
      • 800mg daily for fibromyalgia
      • 400-800mg 3x daily for ADHD
      • 1600mg daily for two weeks to treat bile flow disorders
      • 400-1200mg daily for liver disease

Side effects

Although considered generally safe in moderate doses, side effects, although rare, can include:

Gas, nausea, constipation, diarrhea, headaches and insomnia.

It is important to always start at the lower end of the dosing spectrum and then work your way up to assess tolerance.

If you are taking prescription medicines, always consult with your doctor before starting any supplement to ensure that there are no possible interactions.

We have found Premium Powders SAM-e to be a good source for supplementing this ingredient.

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