Turkesterone is an ecdysteroid, which is a hormonal steroid that is found in plants. Ecdysteroids can be compared to testosterone, due to their ability to induce growth. However, unlike testosterone, ecdysteroids do not bind to androgen receptors, and therefore do not cause any steroidal side effects, such as gynecomastia and hair loss. Although stimulating different anabolic pathways to androgenic steroids, turkesterone seems to be the most anabolic (muscle building) out of all the ecysteriods.
The major advantage of Turkesterone supplements is that they are much safer than anabolic steroids, as although suggestively behaving in a similar way, it does not bind to androgen receptors. Turkesterone also enhances muscle repair and growth by increasing muscle protein synthesis. It’s able to do this by optimising the mRNA translation process and promoting leucine uptake into muscle cells. Due to this effect on protein synthesis, a positive nitrogen balance is attained, which also prevents muscle breakdown. There is also evidence to suggest that ecysteriods, such as turkesterone, are able to increase muscle ATP content, which translates to increased muscular energy and endurance during exercise.
How Does Turkesterone Work?
Turkesterone works by ‘hacking’ the stress response in the body. It does this by regulating a stable balance in the adrenal, pituitary, and hypothalamic glands. These three glands separately produce hormones that help regulate our blood pressure, immune system, mood, vision, growth, and more. By bringing the three glands in harmony, Turkesterone enables users to increase their muscle mass, improve recovery, enhance workloads, and stimulate gains during training. All in all, you can think of Turkesterone as a supplement that promotes a ‘super anabolic effect’.
Turkesterone also has adaptogenic properties, which has beneficial effects on mental health, by alleviating anxiety and mental burnout. Another advantage of using Turkesterone is that it does not require, as it doesn’t amplify testosterone levels. Therefore no suppression occurs following Turkesterone use, which eliminates risk of side effects and promotes muscle gain retention.
Turkesterone Side Effects
Alongside the muscle-building effects of Turkesterone, it also induces multiple beneficial side-effects. Turkesterone can help optimize hormonal levels and strengthen your immune system, which is essential for any active individual. Ecysteriods are also promoted as being healthy for the liver and intestines, as well as being able to lower cholesterol and regulate blood glucose. There is research to suggest that Turkesterone also has protective effects on brain health, through enhancing neurotransmitter activity. However, it is important to avoid taking Turkesterone on an empty stomach as it can cause nausea, which is a common side effect of capsulated supplements.
To attain the muscle-building benefits from Turkesterone it is common for users to run an 8-12 week cycle. However, as this supplement is not androgenic and doesn’t cause suppression, you can run it indefinitely. Although, we do advise an 8-12 week cycle. No PCT is required. The appropriate Turkesterone dosage is 500mg per day.
Clinical Research Studies
Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans
Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in a recent study performed in rats. However, scientific studies in humans are very rarely accessible. Thus, our project aimed at investigating the effects of ecdysterone-containing products on human sport exercise. A 10-week intervention study of strength training of young men (n = 46) was carried out. Different doses of ecdysterone-containing supplements have been administered during the study to evaluate the performance-enhancing effect. Analysis of blood and urine samples for ecdysterone and potential biomarkers of performance enhancement has been conducted. To ensure the specificity of the effects measured, a comprehensive screening for prohibited performance-enhancing substances was also carried out. Furthermore, the administered supplement has been tested for the absence of anabolic steroid contaminations prior to administration. Significantly higher increases in muscle mass were observed in those participants that were dosed with ecdysterone. The same hypertrophic effects were also detected in vitro in C2C12 myotubes. Even more relevant with respect to sports performance, significantly more pronounced increases in one-repetition bench press performance were observed. No increase in biomarkers for liver or kidney toxicity was noticed. These data underline the effectivity of an ecdysterone supplementation with respect to sports performance. Our results strongly suggest the inclusion of ecdysterone in the list of prohibited substances and methods in sports in class S1.2 “other anabolic agents”.
Ecdysteroids: A novel class of anabolic agents?
Increasing numbers of dietary supplements with ecdysteroids are marketed as “natural anabolic agents”. Results of recent studies suggested that their anabolic effect is mediated by estrogen receptor (ER) binding. Within this study the anabolic potency of ecdysterone was compared to well characterized anabolic substances. Effects on the fiber sizes of the soleus muscle in rats as well the diameter of C2C12 derived myotubes were used as biological readouts. Ecdysterone exhibited a strong hypertrophic effect on the fiber size of rat soleus muscle that was found even stronger compared to the test compounds metandienone (dianabol), estradienedione (trenbolox), and SARM S 1, all administered in the same dose (5 mg/kg body weight, for 21 days). In C2C12 myotubes ecdysterone (1 µM) induced a significant increase of the diameter comparable to dihydrotestosterone (1 µM) and IGF 1 (1.3 nM). Molecular docking experiments supported the ERβ mediated action of ecdysterone. To clarify its status in sports, ecdysterone should be considered to be included in the class “S1.2 Other Anabolic Agents” of the list of prohibited substances of the World Anti-Doping Agency.
As a dietary supplement take one (1) or two (2) capsules per day with food, use in cycles of 8-12 weeks.
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