Sleephoria

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EvoMuse’s Sleephoria is an advanced Sleep Restoration Formula! Sleep and Diet are two of the core fundamentals of a happy and productive life. Much like a bad diet will run down your energy, bring on health problems, and make your appearance suffer, a low quality sleeping regimen will do much the same only worse. Chronic sleep problems hinder your body’s ability to renew itself, cripples your immune system, and causes stress hormones to skyrocket.

Sleephoria is defined as that state of euphoria that arises when you get a solid, restful night of sleep…and for many of us that suffer from sleep problems, it is most certainly bliss. Sleep, as we well know, is essential to ideal health, recovery, growth, and optimal performance. The Sleephoria formula has been painstakingly tested and researched to provide a flawless night of sleep, allowing the body and mind to restore itself, without any residual hangover or difficulty waking up the next morning.

For those suffering from occasional or chronic sleeping problems, current solutions are limited and somewhat undesirable. Prescription medications are undoubtedly effective, but can bring with them inconvenience, cost, and some undesirable effects. Over-the-counter sleep aids have been highly limited in the past – often accompanied by a hazy hangover the next morning that could take hours, as well as stimulants, to break. This cycle of taking a sleep aid, then a stimulant in the morning to counter the effect, can cause a vicious cycle.

People have been craving natural solutions to sleep problems, and we took on the challenge: create a potent sleep aid that will gently carry you off to sleep, allow you to dream normally, increase the recovery effect from sleep, and all this without leaving you with a hangover in the morning. Ladies and gentlemen I present to you…Sleephoria.

Due to the long list of ingredients in this formula, we will not be looking at an exhaustive review of the literature on each particular ingredient and all of its functions, instead we will present only the most relevant information relating to sleep, sedation and anxiety for the sake of brevity. However, it should be known that most if not all of the ingredients in Sleephoria have farther reaching effects on overall health and longevity than we have taken the time to dive into in this write up, and we encourage the more curious, science-minded readers to take a look at the more extensive research. But before we get too deeply into the individual ingredients, let’s discuss the GABA system.

The GABA System

GABA is the primary inhibitory neurotransmitter. It tends to reduce exciteability in the central nervous system and help to bring on states of relaxation. So why not simply use GABA? Well, it’s complicated but mostly because the control of sleep states is central, while GABA tends not to be able to cross the blood brain barrier. Ideally, we want to activate GABA receptors while preventing its breakdown for as long as possible during the main period of sleep. So with that background, let’s get into the ingredients.

Sleephoria…Arise and Conquer!

What is in Sleephoria and how will I benefit?

Coriandrum Sativum (standardized to 1% linalool)

Where does it come from?

Linalool is an aromatic chemical found in Coriander, as well as many other plants. Different aromas and neural effects can be expected from different sources of linalool, Coriandrum Sativum (CS) was selected for Sleephoria in part because of its linalool content but also due to other inherent properties relative to sleep and relaxation.

What is it going to do for me?

CS has been shown in animal studies to have anti-anxiety, sedative, muscle relaxant, and sleep prolonging qualities.

Magnolia extract (80% Magnolol/Honokiol)

Where does it come from?

The polyphonic compunds magnolol and honokiol come from the bark of the magnolia officinalis tree found in China where they have been widely used in Traditional Chinese Medicine.

What is it going to do for me?

Research shows that magnolia acts strongly on the GABA(A) receptor, causing decreased sleep latency (time required to fall asleep), and increased quality of sleep. Based on its specific mechanism of action, it has been deemed to be likely effective for use as a sedative as well as an anti-anxiety agent.

Ganoderma lucidum (Ling Zhi)

Where does it come from?

Ling Zhi means “supernatural mushroom”, and has been used in Traditional Chinese Medicine for 2,000 years to treat various ailments.

What is it going to do for me?

Most of the available research on this compound centers around immunomodulation, however; several studies have shined a spotlight on its ability to act as a hypnotic agent, promoting sleep through interaction with the GABA receptor.

Crocin (30% extract)

Where does it come from?

Crocin is a natural carotenoid found in certain flowers.

What is it going to do for me?

Much of the published data on this compound is directed towards its anti-cancer potential, but for our purposes, Crocin has been used successfully in Traditional Chinese Medicine for insomnia and anxiety (). A recent study out of Japan demonstrated that Crocin was able to significantly increase the amount of non-REM sleep measured over a four-hour period.

Withania somnifera/Ashwaghanda (2.5% extract)

Where does it come from?

Ashwagandha is a shrub in the nightshade family, harvested in various regions of India.

What is it going to do for me?

Ashwagandha is an extremely well studied compound with numerous studies supporting its use as an anti-anxiety agent. It has also been studied in conjunction with diazepam to improve sleep quality in a sleep disturbed state.

Ferulic acid

Where does it come from?

Ferulic acid is a phytochemical found in cell walls of plants, as well as in the seeds of artichokes, coffee, apples, peanuts and oranges.

What is it going to do for me?

A recent study out of China demonstrated that Ferulic Acid shortened sleep latency and had a sedative-hypnotic effect, acting through serotonin signaling modulation.

Matricaria recutita (chamomile) extract

Where does it come from?

Chamomile is a flower widely grown all over Europe, Asia, Australia and North America.

What is it going to do for me?

This ingredient was chosen for it’s anti-anxiety properties. A controlled trial published in the Journal of Clinical Psychopharmacology found Chamomile to have anxiolytic effects in patients with Generalized Anxiety Disorder (GAD), and another study done out of Ottawa concluded that Chamomile showed significant inhibition of GAD effects through GABA modulation.

Melissa officinalis L. (lemon balm) extract

Where does it come from?

Melissa officinalis is an herb in the mint family, originating in Europe.

What is it going to do for me?

By inhibiting GABA transaminase (an enzyme that breaks down GABA), Lemon Balm has shown an ability to dampen anxiety and promote a relaxed state in multiple studies.

Stepholidine

Where does it come from?

Stepholidine is a naturally occurring chemical found in the Stephania intermedia herb.

What is it going to do for me?

New research has elucidated Stepholidine as “the first compound found to have a dual function as a dopamine receptor D1 agonist and D2 antagonist”. It has also been shown to interact with the 5-HT(1A) receptor, which deals with serotonin. A paper published in the journal Pharmacology Biochemistry and Behavior highlighted stepholidine as a treatment for insomnia, due to its ability to initiate and maintain NREM sleep.

2-bromomelatonin

Where does it come from?

Melatonin is a hormone produced in the pineal gland of animals, and is also found in plants. 2-bromomelatonin is a brominated version of melatonin with about 10x higher receptor binding affinity over regular melatonin.

What is it going to do for me?

Melatonin is widely accepted as an effective over the counter sleep aid. The brominated version is a supercharged cousin of the original. A study published in the journal Anesthesia & Anelgesia stated that it can exert hypnotic effects similar to Propofol, which is a powerful intravenous sedative administered in hospitals.

Sinapic acid

Where does it come from?

Sinapic acid is found in high bran cereal grains and various herbal materials.

What is it going to do for me?

Through GABA(A) modulation, sinapic acid promotes relaxation and sedation. Results of a paper published in the journal Life Sciences concluded sinapic acid “…is a prominent anxiolytic agent, and its anxiolytic-like effects are mediated via GABA(A) receptors…”.

Valerinic Acid

Where does it come from?

Valerian is one of the most well known and widely used over the counter herbs for inducing relaxation and sedation. Valerinic acid is a constituent of the essential oil of Valerian, believed to be responsible for much of the desired effects.

What is it going to do for me?

Valerinic acid (VA) is another ingredient in the Sleephoria formula that acts on the GABA(A) receptor to induce sedation. In addition to its GABA activity, VA also partially agonizes the 5-HT (5a) receptor, once again involving serotonin. Numerous studies have found valerian and valerinic acid to improve sleep latency, quality of sleep, and induction of sleep.

Whats the recommended dosage for Sleeporia?

Start with one capsule 30 minutes before bed to assess tolerance, then take between 1-3 caps before bed depending on personal preference.

WARNING

Consult your physician before using this or any dietary supplement. Do not take if you are pregnant or breast feeding, elderly, chronically ill, have difficulty urinating due to prostate enlargement, or taking any prescription or over-the-counter medicine, including but not limited to antidepressants (such as MAO inhibitors), allergy medications, and medications for high blood pressure or other cardiovascular conditions. Discontinue use and contact your doctor if you experience dizziness, headache, nausea, or heart palpitations. KEEP OUT OF REACH OF CHILDREN.

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