Conventions of modern society mostly call for us to be civilized in deed and manner throughout the course of daily lives, with the notable exception of athletic pursuit. It’s here, especially in the gym, where full-throttle, single-minded aggressive behavior is not only acceptable, but prized. If your goal is building muscle, lackadaisical simply won’t cut it.
To ensure these brief respites from the civilized world aren’t wasted with anything less than laser-like focus, we’ve created the pre-workout, brain-boosting formula HyStim. Hystim contains several ingredients, both time-tested (caffeine, theobromine and Hyperzine A) and cutting edge (theacrine and N- phenethyldimethylamine) that synergistically stimulate central nervous system arousal and enhance mood. So your muscles can keep up, we’ve also included a convenient dose of ß-alanine in HyStim, to build and maintain muscle carnosine levels, and thus buffering capacity and gym performance.
Pre-Workout Brain Boosting Ingredients:
We couldn’t call this product HyStim if we didn’t include caffeine (350mg of caffeine anhydrous), perhaps the world’s most popular1,2 energy booster3. Caffeine has a wide variety of ergogenic effects4,5 and is both thermogenic6, and lipolytic7, making it a viable staple for any fat loss regimen.
If you’re familiar with Granite Supplement’s line, you know that several of our products showcase what may be the “cleanest” over-the-counter “stimulant” of them all: Theacrine (as 125mg of Tasteless TeaCrine® per dose). Theacrine improves mood, focus, subjective feelings of energy, and motivation to exercise, but actually decreases anxiety8. Even after months of daily use (300mg), TeaCrine® does not lose its effectiveness or hook you into a nasty habit9 [which often happens with caffeine5,10]. [On the other hand, co-administering TeaCrine® with caffeine may actually prevent de-sensitization11.]
The HyStim “alkaloid trinity” is topped off by theobromine (100mg), another mood booster for some individuals12-14 that counterbalances caffeine’s hypertensive (blood pressure elevating) effect15,16. It’s possible that theobromine may synergize with caffeine to promote arousal17 but reduce perceived exertion during exercise because it’s also a bronchodilator11,18-21.
But wait, there’s more! We’ve quadrupled down to ensure HyStim puts you in the right mood to train, by including Huperzia Serrata [the Chinese herb known as Qian Ceng Ta 22], standardized for 1% Huperzine A (yielding 100μg). Hyperzine A is rapidly absorbed 23 and inhibits the acetylcholinesterase enzyme 24,25, thus prolonging the effect of acetylcholine (ACh) in the synapse. Huperzine-A shows promise in improving cognition, mood and spontaneous activity in Alzheimer’s patients (~100-800μg/day) with minimal side effects 22,26,27, but Huperzine A isn’t just for aging brains: Twice / day dosing of 50μg improved memory and learning in middle school students as well 28. As a bonus, Huperzine A seems to be brain healthy, as it protects neurons against injury by a variety of toxins and stresses 22,29.
There’s a new kid on the PEA block and he’s part of the HyStim gang: N-Phenethyldimethylamine (150mg, as citrate salt derived from Eria Jarensis) is a phenylethylamine (PEA) compound 30,31, meaning it’s structurally similar to tyramine (found in cheese, for instance 31], hordenine[found in barley32 Hapke, 1995 #12129}] and many other biogenic amines, such as those found in chocolate 33,34. You’re probably familiar with the PEA derivatives found in our bodies are the catecholamine neurotransmitters (noradrenaline, adrenaline and dopamine)… The mechanistic evidence other several other PEAs suggests that N- Phenylethyldimethylamine’s stimulant actions come via modulating the metabolism of these catecholamines and/or binding to their receptors31.
Intra-Workout Performance Ingredients:
ß-Alanine supplementation fills your muscles’ carnosine tanks35,36, topping off your capacity to buffer acidity during high intensity efforts37. This means a stronger kick at the finish line38, better performance lifting weights35 or doing intervals39, and more importantly, more muscle mass39. The 1.6g dose of ß- alanine found in HyStim alone should produce a modest increase in muscle carnosine levels40, but limit the skin-tingling (paresthesia) side effect37,40 that larger doses of ß-alanine are famous for. [NOTE: Ergogenic effects from ß-alanine are a probably a matter of increasing muscle carnosine over time41. Supplementing with an additional ~3-4g of ß-alanine, spread throughout the day should produce much higher carnosine levels more quickly35,36, but a cumulative dose of ~180g, spread over a longer loading period, should also do the trick41,42.]
Whats the recommended dosage for HyStim?
Mix one scoop (4.3 grams) into 12-16 ounces of cold water and shake or stir. Consume 15 minutes before exercise. Do not consume HyStim within 6 hours prior to taking HyStim. As always, for stronger and sweeter flavor use less water and for weaker use more water. Adjust to the way you like and enjoy.
Research and References
Fredholm BB. Notes on the history of caffeine use. Handb Exp Pharmacol. 2011(200):1-9.
Weinberg BA, Bealer BK. The world of caffeine: the science and culture of the world’s most popular drug. Psychology Press; 2001.
Glade MJ. Caffeine-Not just a stimulant. Nutrition. 2010;26(10):932-938.
Helms ER, Aragon AA, Fitschen PJ. Evidence-based recommendations for natural bodybuilding contest preparation: nutrition and supplementation. Journal of the International Society of Sports Nutrition. 2014;11(1):1-20.
Spriet LL. Exercise and Sport Performance with Low Doses of Caffeine. Sports Medicine. 2014;44(2):175-184.
Belza A, Toubro S, Astrup A. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. Eur J Clin Nutr. 2007;63(1):57-64.
Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Caffeine: a double- blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr. 1990;51(5):759-767.
Ziegenfuss TN, Habowski SM, Sandrock JE, Kedia AW, Kerksick CM, Lopez HL. A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine(R)) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters. Journal of dietary supplements. 2016:1-15.
Taylor L, Mumford P, Roberts M, et al. Safety of TeaCrine®, a non- habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. Journal of the International Society of Sports Nutrition. 2016;13(1):2.
Pohler H. Caffeine Intoxication and Addiction. The Journal for Nurse Practitioners. 2010;6(1):49-52.
Lopez HL, Wells S, Ziegenfuss TN. Theacrine-based supplement and method of use thereof. Google Patents; 2014.
Mumford GK, Evans SM, Kaminski BJ, et al. Discriminative stimulus and subjective effects of theobromine and caffeine in humans. Psychopharmacology (Berl). 1994;115(1):1-8.
Baggott MJ, Childs E, Hart AB, et al. Psychopharmacology of theobromine in healthy volunteers. Psychopharmacology (Berl). 2013;228(1):109-118.
Judelson DA, Preston AG, Miller DL, Munoz CX, Kellogg MD, Lieberman HR. Effects of theobromine and caffeine on mood and vigilance. J Clin Psychopharmacol. 2013;33(4):499-506.
Mitchell ES, Slettenaar M, vd Meer N, et al. Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure. Physiol Behav. 2011;104(5):816-822.
van den Bogaard B, Draijer R, Westerhof BE, van den Meiracker AH, van Montfrans GA, van den Born B-JH. Effects on Peripheral and Central Blood Pressure of Cocoa With Natural or High-Dose Theobromine. A Randomized, Double-Blind Crossover Trial. 2010;56(5):839-846.
Smit HJ, Gaffan EA, Rogers PJ. Methylxanthines are the psycho- pharmacologically active constituents of chocolate. Psychopharmacology (Berl). 2004;176(3-4):412-419.
Simons FER, Becker AB, Simons KJ, Gillespie CA. The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma. Journal of Allergy and Clinical Immunology.76(5):703-707.
Becker AB, Simons KJ, Gillespie CA, Simons FE. The bronchodilator effects and pharmacokinetics of caffeine in asthma. N Engl J Med. 1984;310(12):743-746. 20. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-381.
Feriche B, Chicharro JL, Vaquero AF, Perez M, Lucia A. The use of a fixed value of RPE during a ramp protocol. Comparison with the ventilatory threshold. J Sports Med Phys Fitness. 1998;38(1):35-38.
Ma X, Tan C, Zhu D, Gang DR, Xiao P. Huperzine A from Huperzia species–an ethnopharmacolgical review. J Ethnopharmacol. 2007;113(1):15-34.
Qian BC, Wang M, Zhou ZF, Chen K, Zhou RR, Chen GS. Pharmacokinetics of tablet huperzine A in six volunteers. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1995;16(5):396-398.
Ho Y-S, So K-F, Chang RC-C. Drug discovery from Chinese medicine against neurodegeneration in Alzheimer’s and vascular dementia. Chinese Medicine. 2011;6:15-15.
Liu J-S, Zhu Y-L, Yu C-M, et al. The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity. Canadian Journal of Chemistry. 1986;64(4):837-839.
Yang G, Wang Y, Tian J, Liu J-P. Huperzine A for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. PLoS One. 2013;8(9).
Shu-huai X, Chun-xiao Z, Zhang R, Li A. Huperzine A in the Treatment of Alzheimer’s Disease and Vascular Dementia: A Meta-Analysis. Evidence – Based Complementary and Alternative Medicine. 2014.
Sun QQ, Xu SS, Pan JL, Guo HM, Cao WQ. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1999;20(7):601-603.
Damar U, Gersner R, Johnstone JT, Schachter S, Rotenberg A. Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research. Expert Rev Neurother. 2016;16(6):671-680.
Hedman K, Leander K, Luning B. STUDIES ON ORCHIDACEAE ALKALOIDS. 15. PHENETHYLAMINES FROM ERIA-JARENSIS AMES. Vol 23: MUNKSGAARD INT PUBL LTD 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK; 1969:3261-&.
Lundström J. Chapter 2 β-Phenethylamines and Ephedrines of Plant Origin. In: Brossi A, ed. The Alkaloids: Chemistry and Pharmacology. Vol 35: Academic Press; 1989:77-154.
Poocharoen B. Determination of selected secondary and tertiary amine alkaloids in barley malt [Dissertation]: Food Science and Technology, Oregon State; 1983.
Pastore P, Favaro G, Badocco D, Tapparo A, Cavalli S, Saccani G. Determination of biogenic amines in chocolate by ion chromatographic separation and pulsed integrated amperometric detection with implemented wave-form at Au disposable electrode. Journal of chromatography. A. 2005;1098(1-2):111-115.
P. CJ, Brian C, J. SM. The identification and significance of 2-phenylethylamine in foods. Journal of the science of food and agriculture. 1975;26(5):593-598.
Derave W, Ozdemir MS, Harris RC, et al. beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. J Appl Physiol. 2007;103.
Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids. 2007;32.
Artioli GG, Gualano B, Smith A, Stout J, Lancha AH. Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc. 2010;42.
Van Thienen R, Van Proeyen K, Vanden Eynde P, Puype J, Lefere T, Hespel P. Beta-alanine improves sprint performance in endurance cycling. Med Sci Sports Exerc. 2009;41.
Smith AE, Walter AA, Graef JL, et al. Effects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial. J Int Soc Sports Nutr. 2009;6.
Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta- alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids. 2006;30.
Hobson RM, Saunders B, Ball G, Harris RC, Sale C. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012;43(1):25-37.
Sale C, Artioli GG, Gualano B, Saunders B, Hobson RM, Harris RC. Carnosine: from exercise performance to health. Amino Acids. 2013;44(6):1477-1491.
Arnaud MJ. Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handb Exp Pharmacol. 2011(200):33-91.