DNPX II

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What it means to the select few that have been introduced to ProSupps ™ newest and most potent addition, DNPX II, is complete and utter annihilation of fat and appetite.

With thousands of fat burners on the shelves today, our founder, IFBB Pro Art Atwood knew he needed to formulate a product that combined the perfect balance of thermogenic, appetite suppressant and mental acuity. DNPX was born, and until now, only a select number of people have ever tried this extremely potent and effective formula. Fat stores beware…the X is here.

What kind of results can I expect from supplementing with DNPX II?

Intense Focus

Mental Clarity

Fat Annihilator

Appetite Suppressant

Increase Lipolysis*

Suppress Appetite*

Increase Energy and Focus*

Mental Clarity*

Mood Enhancement*

Fat Oxidation*

Cortisol and Insulin Regulation*

Increase Physical Endurance*

Ingredient Breakdown

White Willow Bark

The White Willow Tree (salix alba), also known as European Willow, is native to central and southern Europe. For centuries the bark from this willow tree, and others such as the Purple Willow Tree (salix purpurea), have been used in traditional medicine for its pain relieving and anti-inflammatory properties. The active ingredient in willow bark is salicin and when consumed our bodies convert this chemical into salicylic acid, similar in structure to modern day aspirin (acetlyl salicylic acid). Often you’ll hear willow bark referred to as “herbal aspirin” as it works in much the same way. The main difference between the two being willow bark will take longer than aspirin to act but its effects may last longer, though willow bark’s pain relieving properties will not be as pronounced as aspirin’s. There is little evidence that willow bark by itself promotes or enhances weight loss. However, when willow bark is combined with thermogenic ingredients such as Caffeine Anhydrous or Yohimbine HCL, it’s thought to extend or enhance their fat burning properties.

Alpha-Yohimbine

A yohimbine-isomer that works with far more potent MAOI-inhibiting properties (normally, yohimbine isn’t very strong in this regard). It basically works as an amphetamine-potentiator, because it prevents the neuro-breakdown of the brain’s ‘big three’– serotonin, noradrenaline, and dopamine. It also has similar alpha-2 antagonistic properties to yohimbine HCl, but is less vasoconstrictive in areas, making it less likely to induce large increases in BP. Alpha-yohimbine (Alpha-Y) is an analogue of yohimbine, but its potency at the subreceptors of alpha2 differ quite a bit–most notably at the alpha2b and alpha2c adrenergic subreceptors. It is 3 times more potent at alpha2b and 4 times more potent at alpha2c. It is equipotent at alpha2a. The differing ratios of activity is where it allows us to do good stuff with it that we could not do with yohimbine.*

Alpha2a mediates most the classic effects of alpha2 receptor agonists and antagonists. There is plenty of info on this in regard to the equipotent yohimbine, so I will not get into it, except to say its superior potency at the other receptors lets us use less to hit them, so we can minimize the negatives here – namely, an increase in heart rate, blood pressure, anxiety, and norepinephrine (NE) hyperactivity, centrally.*

The alpha2c receptor plays a minor role in the negative feedback signal on NE, but it plays a major role in certain brain areas where sympathetic innervation is low, and the dopamine system is prominent, which just happen to be the areas that are critical for reward, reinforcement, and metabolic control, such as the VTA and striatum. In these areas, dopamine–not NE–is the primary agonist at alpha 2 receptors, and alpha2c makes up the majority of these receptors. So, it will block dopamine’s negative feedback signal, thus increasing dopaminergic tone.*

If that were not handy enough, the only other place the alpha2c receptors are highly expressed is in the adrenal medulla, where it modulates negative feedback on epinephrine (E), much like alpha2a does on NE. In other words, alpha-y allows for a much greater increase in E levels, with its superior effect on thermogenesis, energy expenditure, and nutrient partitioning.*

The alpha2b receptor is prominent in development (it is the only adrenergic deletion that impacts survival), but in adults, it only affects blood pressure. Namely, it increases the hell out of it, especially in regard to salt loading. In the obese, and with overfeeding, receptor levels are upregulated. Not coincidentally, it also increases Arginine vasopressin activity. So, not only are we minimizing the increase in the alpha2b agonist NE, we are blocking the receptor more strongly than with yohimbine.*

Caffeine Anhydrous

Caffeine anhydrous is simply caffeine in dehydrated form, without the water. If one takes a pill containing caffeine anhydrous, one might as well drink a cup of coffee for the same effect, although the concentration of caffeine may differ between the two. Rather than paying much attention to words portraying caffeine anhydrous as some new miracle drug, simply think “caffeine”. That’s not to say there’s anything wrong with caffeine anhydrous pills or supplements. They are known to have value in a weight reduction program as, like the caffeine in coffee, they speed up the metabolism causing calories to be burned at a morerapid rate. The pills can also be a powerful stimulant.*

3, 5-Diiodo-L-Thyronine

Recent evidence suggests that 3,5-diiodo-L-thyronine (T2), a naturally occurring iodothyronine, stimulates metabolic rate via mechanisms involving the mitochondrial apparatus. In addition, T2 can induce metabolic inefficiency, possibly by stimulating energy loss via mechanisms involving mitochondrial proton leakage/redox slippage. Such inefficiency in energy transduction should result in reduced energy storage. In view of these metabolic effects of T2 and the very low affinity of T2 for nuclear T3 receptors, we thought it conceivable that in rats fed a high-fat diet (HFD), long-term treatment with T2 might result in a reduced adiposity and less body weight gain without inducing a clinical syndrome related to the thyrotoxic state. 3,5-diiodo-l-thyronine (T2) has been shown to exert marked effects on energy metabolism by acting mainly at the mitochondrial level. Here we investigated the capacity of T2 to affect both skeletal muscle mitochondrial substrate oxidation and thermogenesis within 1 hr after its injection into hypothyroid rats. Administration of T2 induced an increase in mitochondrial oxidation when palmitoyl-CoA (+104%), palmitoylcarnitine (+80%), or succinate (+30%) was used as substrate, but it had no effect when pyruvate was used. T2 was able to 1) activate the AMPK-ACC-malonyl-CoA metabolic signaling pathway known to direct lipid partitioning toward oxidation and 2) increase the importing of fatty acids into the mitochondrion.

These results suggest that T2 stimulates mitochondrial fatty acid oxidation byactivating several metabolic pathways, such as the fatty acid import/β-oxidation cycle/FADH2-linked respiratory pathways, where fatty acids are imported. T2 also enhanced skeletal muscle mitochondrial thermogenesis by activating pathways involved in the dissipation of the proton-motive force not associated with ATP synthesis (“proton leak”), the effect being dependent on the presence of free fatty acids inside mitochondria.

We conclude that skeletal muscle is a target for T2, and we propose that, by activating processes able to enhance mitochondrial fatty acid oxidation and thermogenesis, T2 could play a role in protecting skeletal muscle against excessive intramyocellular lipid storage,possibly allowing it to avoid functional disorders. adenosine 5′-monophosphate, thyroid hormone, mitochondria among the endocrine factors able to regulate substrate metabolism and thermogenesis, thyroid hormones (THs) play important roles. 3,5,3′-Triiodothyronine (T3) exerts a plethora of effects, including upregulation of peripheral and hepatic glucose uptake, cholesterol reduction, loss of body weight and adiposity, cardiac acceleration, and increases in metabolic rate. In adults, T3 regulates energy metabolism by increasing respiration and energy expenditure and by lowering metabolic efficiency. Because of this, T3 was tested in the past as an antiobesity and hypolipidemic agent.*

O-methoxy phenyletylamine, Beta phenylethylamine, 4-hyroxyphenylethylamine, N-dimethyl-hydroxyphenletylamine(PEA)

Well, besides being terribly difficult to pronounce Phenylethylamine, or PEA is an ingredient that can be found in a few weight loss products. Phenylethylamine can be found in chocolate (as well as many illegal drugs like LSD). Phenylethylamine, or PEA, is a neuromodulator, which is responsible for the transmission of norepinephrine and dopamine. PEA is also known as the “love drug”, and is the primary reason why chocolate is considered an aphrodisiac. This is a much more efficient way to experience the mood enhancing properties of chocolate without the fat and extra calories.

Phenylethylamine is a stimulant which some also believe has the ability to suppress the appetite and strongly enhance mood. Phenylethylamine also elevates mental alertness because it releases acetylcholine, which supports memory and cognitive skills, such as concentration.*

5-Hydroxytryptophan-5 HTP

As a metabolic intermediate for the biosynthesis of Serotonin and Melatonin from Tryptophan, 5-Hydroxytryptophan (5-HTP), a naturally occurring amino acid, is widely used as an OTC dietary supplement for the effective treatment of depression, chronic headaches, pre-menstrual syndrome, over eating and sleeplessness. Many people who experience depression seek to elevate their Tryptophan/Serotonin levels by consuming a diet low in protein and high in carbohydrates and processed foods; the higher the protein intake, in fact, the harder it is for them to establish normal Tryptophan levels in the brain. With the addition of 5-HTP, Serotonin levels can be boosted without the extreme practice of overeating. 5-HTP will also diminish one’s appetite to prevent them from gorging on the wrong foods. Therefore, weight loss and improved mental function are the major benefits of supplementing with 5-HTP.*

Black Tea

Tea is the most-consumed hot beverage all over the world. Tea is available in different forms like black tea, green tea and white tea, depending on its ingredients. Black tea is prepared from a plant called Camellia sinesis. The old leaves and the stem of the plant are used in the preparation of black tea. Black Tea improves the mental alertness of patients suffering from severe stress and depression and prevents aggravation of the condition. It improves the memory and learning skills of the person. Lack of these skills can lead to depression and stress in patients. Consuming black tea improves these skills and reduces stress. It enhances our information processing skills. It helps in rapid analysis by our brain and thus helps in avoiding stressful conditions. It helps in reducing repeated attacks of headache in patients suffering from stress and depression. Drinking black tea increases the basal metabolic rate of the body, which helps in increasing the energy consumption of our body. The food that is eaten is utilized by the body at a faster rate. Thus, black tea can help in reducing the calorie intake of our body. Also, black tea can burn fat at a higher rate and so helps obese people to get rid of excess fat in the body. The fat is mobilized from the fat deposits and converted into energy for its utilization at an increased rate. This helps patients who want to lose weight. Black tea contains several anti-oxidants that help in detoxifying our body to get rid of unwanted toxins.

So, black tea assists in weight loss in a healthy manner unlike other methods used for weight loss. Hence, it can be concluded that there are several benefits of black tea for stress, diabetes, and weight loss in patients suffering from them. It should be noted that black tea may lose some of its beneficial properties if mixed with milk. Regular consumption of black tea can help patients to relieve their anxiety and live a stress-free life. It can benefit a lot of people as it helps in prevention of diabetes, which is the most common metabolic disease all over the world. It helps obese patients in their weight loss programs as it helps in reducing their weight in a harmless and healthy manner. Consuming black tea will help in weight loss when coupled with dietary restrictions and regular exercises.*

The Core Four

L-Carnitine: Responsible for the transport of fats into the cells to be used for energy in the body. By raising the level of muscle carnitine, you support the fat burning process, and because your body becomes more efficient at processing fuel, it will increase your energy levels. Elevating carnitine will also improve physical performance by burning more fat, sparing glycogen, clearing muscle lactate, and increasing anabolic hormone response.

Choline Bitartrate: The combination of caffeine, carnitine and choline supplementation decreases body fat and serum leptin concentration in rats, and increases fat utilization for energy. Leptin is a protein hormone that regulates energy intake and expenditure, including appetite and hunger, metabolism and behavior. Choline plays a role in the oxidation of fatty acids, carrying them out of the liver and to the mitochondria of skeletal muscle cells and other metabolically active tissue.

Green Coffee Bean: The chlorogenic acid found in unroasted green coffee beans has been shown to inhibit an enzyme, glucose-6-phosphatase, an enzyme involved in the release of sugar for energy use. By inhibiting the availability of glucose for energy, the body then is forced to turn to alternate sources of fuel, namely fats. The end result is safe and effective weight loss and a change in body composition by tricking your body into preferentially using fat as fuel.

ADILASE™: An exclusive specialized extract of Hemerocallis fulva, designed to maximize the release of fat from stubborn cells. ADILASE™ helps stimulate fat cells to release fat into the bloodstream. Many people struggle to lose fat with ‘typical’ high-stimulant fat burners due to a condition called lipolytic catecholamine resistance, which means that their fat cells do not readily release fat when stimulated to do so. When ADILASE™, is combined with caffeine, it improves the lipolytic (fat releasing) sensitivity in low-responding fat storage cells, indicating that the lipolysis-promoting activity of this combination may be beneficial for improving body fat metabolism.

The Diablo Inferno Complex

6AM™–Aframomum melegueta extract: A specialized extract of ‘Grains of Paradise’, the fat fighting potent seeds from Africa. Clinical trials exploring the weight loss benefits of 6AM™ found that it can significantly increase energy expenditure and loss of brown adipose (fat) tissue. One of the key ingredients involved in the thermogenic response is 6-paradol, a pungent aromatic ketone also found in ginger.

Evodiamine: A capsaicin-like alkaloid that acts as a vanilloid receptor agonist, without the peppery hot taste. Like capsaicin Evodiamine increases body heat production and raises resting core temperature, increasing the calories and fat that are burned for energy. The stimulant and appetite suppressant effects of evodiamine can be attributed to its effects on catecholamine levels. Evodiamine increases the release of catecholamines such as adrenaline and dopamine from the adrenal glands, increasing energy levels and decreasing appetite.

Pheneylethylamine HCI (PEA): A monoamine alkaloid that can improve mood, mental acuity, energy and focus. Although relatively short-lived, when combined with and MAO inhibitor, the effects can be prolonged. Part of sticking to a diet plan involves feeling good and staying motivated and PEA can help you keep a positive frame of mind.

Hordenine: Has been known as a central nervous stimulant that helps to aid in the effects of weight loss. It assists in the release of fat cells for energy and helps the process of slowing down food digestion, which in turn can make you feel fuller longer. It also acts as a mild MAO inhibitor, thereby prolonging the effects of monoamine alkaloids like PEA.

What dosage should I take?

SUPPLEMENT ADVISORY EXTREMELY POTENT. DNPX II is a powerful dietary supplement and is intended for use by healthy adults over the age of 18. Do not use any other caffeine products in combination with DNPX II. As a Dietary Supplement Take 1 Capsule in the morning. Do not exceed more than 1 capsule at a time or 2 capsules in a 24 hour period.

WARNING

Not for use by individuals under the age of 18 years. Do not use if pregnant or nursing. Keep out of the reach of children. Do not consume this product if you have a medical condition and/or taking any prescription medication. Do not exceed recommended servings. Do not use this product if you are at risk or are being treated for high blood pressure, kidney, thyroid or psychiatric disease, anxiety, depression, seizure, enlarged prostate or stroke. Before beginning any supplement or training program always consult a physician first.

*”These statements have not been evaluated by the Food & Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. ALWAYS consult your physician before taking supplements.”

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