By combining cutting-edge pharmaceutical-grade ingredients with tried-and-tested high-quality herbal extracts, new Achilles from Antaeus Labs brings you the most advanced joint-support formula on the market!
Every hero has a weakness. For many weightlifters and bodybuilders this is their joints. Tendons and ligaments bear the brunt of punishing weight-lifting sessions, commonly becoming inflamed and sore. The connective tissue just can’t keep up with the heavier and heavier weights lifted week after week. Niggling pains become chronic injuries, often requiring a forced rest, a change of routine or the permanent dropping of some exercises altogether.
Achilles Ingredient Breakdown
40 years of scientific research has established Palmitoylethanolamide (PEA) as one of the most important endogenous painkilling and anti-inflammatory compounds. The naturally occurring fatty acid amide palmitoylethanolamide is an agonist of the peroxisome proliferator-activated receptor alpha (PPAR-α).  PPAR-α agonists have been shown to be effective for both acute and chronic pain. 
PEA can modulate pain sensitivity (nociception) by regulating mast cells.  Mast cells release bioactive mediators like histamine (that dilates blood vessels leading to swelling, redness, and warmth ) and nerve growth factor (that produces inflammation and sensitization of pain-sensing neurons ).
Brazilian traditional medicine uses H. aphrodisiaca for, among other things, muscle and bone weakness – use that has been borne out recently when a study found that H. aphrodisiaca-treated trained rats had stronger tendons that could take a bigger load and more stress than untreated trained rats. 
“H. aphrodisiaca associated with endurance training contributed to more efficient remodeling of the extracellular matrix, resulting in more resistant tendons to support high loads from intense muscle contraction. These findings suggest that H. aphrodisiaca infusion is a potential aid to optimize tendon remodeling in athletes.” 
Whats the recommended dosage for Achilles?
As a dietary supplement, take four capsules daily with food. We recommend two capsules with the first meal of the day and two capsules with the last meal of the the day. Do not exceed six capsules in any 24 hour period.
Research and References:
 Verme JL, Fu J, Astarita G, Rana GL, Russo R, Calignano A, et al. The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide. Mol Pharmacol. 2005 Jan 1;67(1):15–9.
 Fehrenbacher JC, Loverme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK. Rapid pain modulation with nuclear receptor ligands. Brain Res Rev. 2009 Apr;60(1):114–24.
 Mazzari S, Canella R, Petrelli L, Marcolongo G, Leon A. N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation. Eur. J. Pharmacol. 1996 Apr 11;300(3):227–36.
 Prussin C, Metcalfe DD. 4. IgE, mast cells, basophils, and eosinophils. J. Allergy Clin. Immunol. 2003 Feb;111(2 Suppl):S486–494.
 Nicol GD, Vasko MR. Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks? Mol. Interv. 2007 Feb;7(1):26–41.
 Monteiro JC, Gomes ML, Tomiosso TC, Nakagaki WR, Sbervelheri MM, Ferrucci DL, et al. More resistant tendons obtained from the association of Heteropterys aphrodisiaca and endurance training. BMC Complementary and Alternative Medicine. 2011 Jun 28;11(1):51.
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