Intra Keto

Granite Supplements provides cutting edge, healthful nutritional tools to complement your bodybuilding strategic plan. Whether you’re generally restricting carbohydrate (e.g., keto-dieting) or simply prefer a lighter, carb-free intra-workout recovery drink, we’ve created Intra-Keto, a low-carb, ketone- enriched version of Recovery [but sweetened with “keto-friendly” erythritol1,2].

We’ve included some of the recovery and performance perks of Recovery [electrolytes, essential amino acids (EAAs)] in Intra-Keto, to ensure hydration and anabolism / anti-catabolism, but replaced carbohydrate with ß- hydroxybutyrate, so you now have the flexibility to:

Build upon an entry-level dose of ketone bodies (as goBHBTM ß- hydroxybutyrate salts) by supplementing with additional ketone bodies and/or medium chain triglycerides3.

Focus your nutrient timing towards pre- and/or post-workout carbohydrate intake (e.g., eat more whole foods).

Intra-Keto is a unique nutritional performance and recovery tool. In addition to the major electrolytes lost in sweat4 [to help keep you well hydrated5,6], we’ve included a synergistic combination of three ingredients:

Ketone bodies as ß-hydroxybutyrate salts

Essential Amino Acid blend for anabolism / anti-catabolism

Sensoril® Ashwagandha extract for its adaptogenic effects

Essential Amino Acid Blend

We included the Essential Amino Acid (EAA) blend because it’s the essential [not the non-essential7] amino acids that trigger muscle protein synthesis8-10. Leucine (3g) sits atop this EAA stack because of it’s primacy in triggering protein anabolism11-13. We were sure focus on the other branched chain aminos (BCAAs; Isoleucine and Valine at 1.5g each) as well, because the BCAAs are known to reduce muscle breakdown and post-exercise soreness and damage14,15.

The other EAAs blended in Intra-Keto are based on the anabolic EAA mixture used extensively in research8,16-19, adjusted slightly to take advantage of the anabolic signaling12 and insulin-releasing20 effects of lysine and phenylalanine.

Ketone Bodies

Intra-Keto contains 4,600mg (4.6g) of (goBHBTM) ß-hydroxybutyrate (BHB) salts, a hearty entry-level dose of this ketone body. By building upon this with additional BHB salts, or ideally, a ketone ester supplement, blood ketone levels can be elevated dose-dependently21-24. [Unfortunately, the extremely viscous, oily and bitter25 nature of available ketone monoesters would make a sticky, nasty mess out of the Intra-Keto powder.] Still, low dose of BHB salts (~17g for a 220lb bodybuilder) can rapidly elevate blood BHB21 to levels normally seen only after 1-2 days of fasting26, and the same dose of BHB esters can almost double peak BHB levels21. [NOTE: That amount of BHB salt would mean a large acid/salt load, but adding (caprylic and capric acid- based) medium chain triglyceride can make BHB salts much more ketogenic3,27.]

While the data are very sparse22, elevating blood ketones may serve as an alternate fuel to enhance endurance performance25, suppress appetite28, enhance cognition29,30 and possibly reap other metabolic benefits of ketosis24,31-33. Anecdotal reports of a positive cognitive effect of consuming ketones pre-exercise are supported mechanistically30, so you may feel energized by the BHB in Intra-Keto. On the other hand, a recent study found that a 0.3g/kg dose (~30g for a 220lb bodybuilder – much larger than the dose in Intra-Keto) of BHB salts impaired high intensity cycling exercise performance34, possibly by forcibly shifting metabolism toward fats22,25 and away from the vital carbohydrate needed during high intensity efforts35,36.

Sensoril® Ashwagandha Extract

A successful training and diet cycle takes weeks of committed and continuous effort. Nobody wants to be a flash in the pan, so to speak, so we’ve included ashwagandha (Withania somnifera extract; 125mg of Sensoril® stardardized for withanolide glycoside conjugates, oligosachharides and withaferin A) to ensure Intra-Keto keeps you adapting long after your workout. Also known as Indian ginseng, ashwagandha is an “adaptogenic” herb that’s been used for centuries in Ayurveda and traditional Indian medicine to relieve stress, promote vitality37, enhance adaptation and normalize physiological function38-40.

Whats the recommended dosage for Intra Keto?

Mix one scoop (27g) into 12-16 ounces of water and shake or stir. Consume 30-40 minutes prior to training. As always, for stronger and sweet flavor use less water and for weaker use more water. Adjust to the way you like and enjoy.

WARNING

KEEP OUT OF THE REACH OF CHILDREN. Store at room temperature, tightly closed. Aviod excessive heat. Some product clumping may occur.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Research and References:

Wolnerhanssen BK, Cajacob L, Keller N, et al. Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects. Am J Physiol Endocrinol Metab. 2016;310(11):E1053-1061.

Edson NL. Ketogenesis-antiketogenesis: Substrate competition in liver. Biochemical Journal. 1936;30(10):1862.

Kesl SL, Poff AM, Ward NP, et al. Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats. Nutr Metab (Lond). 2016;13(1):9.

Sawka MN, Burke LM, Eichner ER, Maughan RJ, Montain SJ, Stachenfeld NS. American College of Sports Medicine position stand. Exercise and fluid replacement. Med Sci Sports Exerc. 2007;39(2):377-390.

Maughan RJ, Owen JH, Shirreffs SM, Leiper JB. Post-exercise rehydration in man: effects of electrolyte addition to ingested fluids. Eur J Appl Physiol Occup Physiol. 1994;69(3):209-215.

James LJ, Shirreffs SM. Effect of electrolyte addition to rehydration drinks consumed after severe fluid and energy restriction. J Strength Cond Res. 2015;29(2):521-527.

Tipton KD, Gurkin BE, Matin S, Wolfe RR. Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers. J Nutr Biochem. 1999;10(2):89-95.

Borsheim E, Tipton KD, Wolf SE, Wolfe RR. Essential amino acids and muscle protein recovery from resistance exercise. American journal of physiology. Endocrinology and metabolism. 2002;283(4):E648-657.

Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr. 2003;78.

Smith K, Reynolds N, Downie S, Patel A, Rennie MJ. Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein. Am J Physiol. 1998;275(1 Pt 1):E73-78.

Eriksson S, Hagenfeldt L, Wahren J. A comparison of the effects of intravenous infusion of individual branched-chain amino acids on blood amino acid levels in man. Clin Sci (Lond). 1981;60(1):95-100.

Atherton PJ, Smith K, Etheridge T, Rankin D, Rennie MJ. Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells. Amino acids. 2010;38(5):1533-1539.

Churchward-Venne TA, Burd NA, Mitchell CJ, et al. Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. The Journal of physiology. 2012;590(Pt 11):2751-2765.

Shimomura Y, Inaguma A, Watanabe S, et al. Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness. International journal of sport nutrition and exercise metabolism. 2010;20(3):236-244.

Coombes JS, McNaughton LR. Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise. The Journal of sports medicine and physical fitness. 2000;40(3):240-246.

Tipton KD, Borsheim E, Wolf SE, Sanford AP, Wolfe RR. Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion. Am J Physiol Endocrinol Metab. 2003;284(1):E76-89.

Tipton KD, Rasmussen BB, Miller SL, et al. Timing of amino acid- carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am J Physiol Endocrinol Metab. 2001;281(2):E197-206.

Rasmussen BB, Wolfe RR, Volpi E. Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly. J Nutr Health Aging. 2002;6(6):358-362.

Rasmussen BB, Tipton KD, Miller SL, Wolf SE, Wolfe RR. An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. Journal of applied physiology. 2000;88(2):386-392.

Floyd JC, Jr., Fajans SS, Conn JW, Knopf RF, Rull J. Stimulation of insulin secretion by amino acids. J Clin Invest. 1966;45(9):1487-1502.

Stubbs BJ, Evans R, Clarke K, Cox PJ. Ketone ester drinks increase blood ketone levels more effectively than ketone salt drinks. Paper presented at: Proceedings of The Physiological Society2016.

Pinckaers PJM, Churchward-Venne TA, Bailey D, van Loon LJC. Ketone Bodies and Exercise Performance: The Next Magic Bullet or Merely Hype? Sports Medicine. 2016:1-9.

Evans M, Cogan KE, Egan B. Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation. The Journal of Physiology. 2016.

Veech RL. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids. 2004;70(3):309-319.

Cox Pete J, Kirk T, Ashmore T, et al. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell Metab. 2016;24(2):256-268.

Hashim SA, VanItallie TB. Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester. J Lipid Res. 2014;55(9):1818-1826.

D’Agostino DP, Arnold P, Kesl S. Compositions and methods for producing elevated and sustained ketosis. Google Patents; 2015.

Gibson AA, Seimon RV, Lee CM, et al. Do ketogenic diets really suppress appetite? A systematic review and meta-analysis. Obes Rev. 2015;16(1):64- 76.

Reger MA, Henderson ST, Hale C, et al. Effects of β-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004;25(3):311-314.

Kashiwaya Y, Bergman C, Lee J-H, et al. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer’s disease. Neurobiol Aging. 2013;34(6):1530-1539.

Kossoff EH, Dorward JL, Turner Z, Pyzik PL. Prospective study of the modified atkins diet in combination with a ketogenic liquid supplement during the initial month. J Child Neurol. 2011;26(2):147-151.

Newport MT, VanItallie TB, Kashiwaya Y, King MT, Veech RL. A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer’s.

Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2015;11(1):99-103.

Seyfried TN, Flores RE, Poff AM, D’Agostino DP. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 2014;35(3):515-527.

O’Malley T, Myette-Cote E, Durrer C, Little JP. Nutritional ketone salts increase fat oxidation but impair high-intensity exercise performance in healthy adult males. Applied Physiology, Nutrition, and Metabolism. 2017;42(10):1031-1035.

Coyle EF. Substrate utilization during exercise in active people. Am J Clin Nutr. 1995;61(4 Suppl):968s-979s.

Romijn JA, Coyle EF, Sidossis LS, et al. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol. 1993;265(3 Pt 1):E380-391.

Auddy B, Hazra J, Mitra A, Abedon B, Ghosal S. A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study. Vol 112008.

Sudha P, Reni A. 2 Ashwagandha. Leafy Medicinal Herbs: Botany, Chemistry, Postharvest Technology and Uses. 2016:19.

Winters M. Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern Med Rev. 2006;11(4):269-277.

Sandhya S, Sushil K. Withania somnifera: the Indian ginseng ashwagandha. Central Institute of Medicinal and Aromatic Plants; 1998.