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SAMe Capsules



Product Information

SAMe not only plays an important role in the immune system, it also helps maintain cell membranes. SAMe produces and breaks down certain chemicals in the body. These chemicals, such as serotonin, melatonin, and dopamine, play an important role in pain, depression, liver disease, and other conditions. SAMe or S-Adenosyl Methionine can help with emotional well-being, joint health and its a natural antioxidant.


Premium Powders S-Adenosyl Methionine Tosylate Disulfate (SAMe) is a naturally occurring chemical found in almost every tissue and fluid in the body but cannot be found in food. It is only produced by the body or made in a laboratory and supplemented.

  • Joint Health
  • Emotional Well-Being
  • Powerful Antioxidant
  • HPLC Tested for potency and purity

Recent Research

According to the University of Maryland Medical Center (UMMC), there are numerous scientific studies showing that SAMe helps relieve the pain of Osteoarthritis. Clinical trials show SAMe may reduce pain and inflammation in the joints. Researchers also believe it may promote cartilage repair. Short term studies show that in adults with knee, hip, or spine Osteoarthritis,  SAMe is as effective as non-steroidal anti-inflammatory drugs (NSAIDs), such as Ibuprofen and Naproxen.

There has also been research on the use of SAMe in treatment of liver disease and Fibromyalgia.

According to UMMC, preliminary studies suggest that taking SAMe may help treat chronic liver disease caused by medications or alcoholism. "A study of 123 men and women with alcoholic liver cirrhosis (liver failure) found that SAMe treatment for 2 years improved survival rates and delayed the need for liver transplants better than placebo. Other studies show that SAMe may help normalize levels of liver enzymes in people with liver disease. Studies in mice show that SAMe protects against and can also reverse liver damage."


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SAMe works with Vitamin B12 and Vitamin B6. If supplementing with SAMe, we suggest you also consider our Mega B Complex to avoid deficiency of essential B Vitamins.


Studies suggest that SAMe is more effective than placebo in treating mild-to-moderate depression. Dr. Oz also supports SAMe as a top natural anti-depressant.

What kind of results can I expect from supplementing with SAMe?

  • Enhanced Joint Strength
  • Promotes Cartilage Repair and Production of Healthy Connective Tissue
  • Reduction in Pain from those suffering from Osteoarthritis, Fibromyalgia, and other Degenerative Diseases
  • Promotes Healthy Levels of Liver Enzymes and may Reverse Liver Damage
  • Reduced Symptoms from Mild-to-Moderate Depression
  • May Inhibit Cancer Tumor Cells

Who should supplement with SAMe?

  • Anyone suffering from chronic pain related to Arthritis, Osteoarthritis, or Fibromyalgia
  • People suffering from Mild-to-Moderate Depression
  • People with liver disease or liver damage
  • People with deficiencies of Vitamins B6 or B12
  • Women suffering from PMS or PMDD should consider supplementing with SAMe

Who should NOT supplement with SAMe?

  • Pregnant or nursing women
  • Anyone suffering from Bipolar Disorder
  • People suffering from Parkinson’s
  • Anyone with scheduled surgery within two weeks

What dosage should I take?

As a dietary supplement, take one serving (400mg) twice daily or as recommended by your physician.

What side effects can I expect?

SAMe is likely safe for most adults. It can in some cases cause gas, vomiting, and diarrhea or constipation. Rare side effects may include but are not limited to dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness, especially at high doses.


KEEP OUT OF REACH OF CHILDREN. This product is intended for adults only. Not for use for anyone under 18 years of age, pregnant or nursing women. If you have had a medical condition or are currently using prescription drugs consult your physician before using this product. Avoid this product if you have any previous history of medical dysfunction or disease including but not limited to kidney disease. Discontinue use and consult your doctor if any adverse reactions occur.

As with any dietary supplement, we recommend that you consult a physician before use.


"These statements have not been evaluated by the Food & Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. ALWAYS consult your physician before taking supplements."

California’s Proposition 65

WARNING: Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause cancer and birth defects or other reproductive harm.

California’s Proposition 65 requires a warning applicable ONLY TO CALIFORNIA CONSUMERS – this warning does not apply to consumers in any other U.S. state or other countries.

This warning statement is a requirement under California’s Safe Drinking Water and Toxic Enforcement Act of 1986 or “Proposition 65” as it is more commonly known.

Please note that this warning does not mean that any particular product is unsafe or in violation of any product safety standard or requirement.

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