PRE-MIUM

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It’s time to train… Are you ready?… We’re not asking about whether your training strategy, your diet or your gym bag is in order… 

 

The question is: Are you ready to manifest the physique you see in your mind’s eye? Are you building up your focus, laser like intention, and the unbreakable mental strength that will ensure that this workout really matters?… 

 

This is what Pre-Mium is all about: Priming you physiologically and psychologically to perform optimally. We’re talking about generating the mental fortitude to blast you through the physiological barriers, workout by workout, that stand in the way of the your physique, strength and human performance goals. 

 

Pre-Mium takes a three-pronged approach in preparing you for superhuman efforts:

L-Citrulline for a Great Pump

A Performance blend for a productive workout: Creatine, ß-Alanine and Betaine

A Cognitive blend to keep your mind sharp: Lion’s Mane plus Theacrine, Caffeine, Theobromine, and N-Acetyl-Tyrosine!

Each Blend has been carefully formulated with ingredients in clinically tested doses – you won’t find Granite supplements “fairy-dusted” with miniscule amounts to fancy up the label. Additionally, we includes a smaller dose of ß-Alanine (Carnosyn®) upon which a more aggressive supplement regime can be built (e.g., by supplementing at other times of the day.

L-Citrulline for a Great Pump

Helping you get a great pump is just one way Pre-Mium can promote muscle gains1, not to mention make you feel great and look phenomenal during your workout.

The hefty 6g dose2 of L-Citrulline (as both free form and as DL Malate) in Pre-Mium bolsters nitric oxide synthesis by elevating both arginine3 and nitrite4!], thus opening up blood vessels to allow more blood into active muscle, while improving exercise performance2,5,6. L-Citrulline may also diminish muscle soreness5, and thus aid recovery7!

L-Citrulline is a healthy supplement, to boot, as it has the potential to support compromised heart contractility8, as well as enhance immune function9, and even protect against injury to the gut (GI tract)10.

Performance Blend

Everyone loves a great pump, but it’s mechanical overload and metabolic stress – the heavy and hard, fatiguing (and painful) training – that are tried and true muscle growth signals11-16. In other words, outrageous gym performances goes hand in hand with outrageous physiques, and the Pre-Mium Performance Blend exploits the synergy17 of 3 ergogenic ingredients (in scientifically-backed dosages) to put you on the path to outrageousness:

 

Creatine monohydrate is a supplement staple18 for good reason: It increases performance19, muscle and strength gains20,21, and is intrinsically anabolic22. We intentionally put Creapure® creatine into the Pre-Mium – as part of a pre-workout formulation – to make use of the creatine-loading effect of muscle contraction21,23,24. For an even better creatine-loading effect, you can emply an intra-workout carb source (like Recovery or Intra-Carb). Why you ask?.. The pairing of creatine alongside carbohydrate means both more creatine storage25 as well as more glycogen storage26. Thus, intra- workout carbs (plus creatine) means higher glycogen levels27 and sustained performance during your workout28,29.

 

ß-Alanine supplementation fills your muscles’ carnosine tanks30,31, topping off your capacity to buffer acidity during high intensity efforts32. This means a stronger kick at the finish line33, better performance lifting weights30 or doing intervals34, and more importantly, more muscle mass over the long haul34. [In other words, we’ve stacked ß-alanine with creatine in Pre-Mium to give you better gains35,36.] The 1.8g dose of ß-alanine (as patented Carnosyn®) found in Pre-Mium alone should produce a modest increase in muscle carnosine levels37, but limit the skin-tingling (paresthesia) side effect32,37 that larger doses of ß-alanine are famous for. [NOTE: Ergogenic effects from ß-alanine are a probably a matter of increasing muscle carnosine over time38. Supplementing with ~3-4g of additional ß-alanine, spread throughout the day, should produce much higher carnosine levels more quickly30,31, but a cumulative dose of ~180g, spread over a longer loading period, should also do the trick38,39.]

 

Found naturally in food, Betaine is cell volumizer (osmolyte) and source of methyl groups, meaning it’s good for the liver and kidney40, and used in the synthesis of molecules like creatine and carnitine41. Betaine is both ergogenic and inherently anabolic: Just two weeks of supplementation (2.5g/d via 2 x 1.25g doses) can increase bench and squat performance, jumping power42-44, and make fatiguing exercise feel easier45. When fed to growing livestock, betaine increases muscle gains and reduces body fat41. More importantly, in exercising humans (like you, you animal!), the same modest dosing regime is enough to amplify both the intracellular anabolic signaling and reduce blood cortisol46, both of which can mean more muscle growth47,48.

 

The performance blend may also carry have health benefits. Creatine supplementation may protect against heat, musculoskeletal injury and neurodegeneration20. Both creatine and betaine are heart friendly via their anti-inflammatory effects49-52 and by lowering blood homocysteine levels53- 55, a predictor of heart disease56. Additionally, evidence is starting to accumulate that increasing carnosine levels via ß-alanine supplementation could theoretically have anti-tumor and anti-diabetic effects39.

Cognitive Blend

The rubber meets the road – hard – with Pre-Mium’s Cognitive Blend. When it’s time to blast through your workout with laser-like focus, count on Pre-Mium is an energy source to turbo-charge your willpower. 

 

We’ve included 500mg of a concentrated (4:1) Lion’s Mane (Hericium erinaceum) extract in Pre-Mium because of its nootropic effects: It can both increase alertness during the waking hours, while supporting restful sleep at night57, vital for recovery58. While medicinal mushrooms like Lion’s Mane are largely unexplored, relative to the large number of mushroom species on the planet earth59, there are growing number of studies of their bioactive compounds60. This especially holds true for Lion’s Mane61, which has demonstrated beneficial psychoactive62,63, neurotrophic64,65, anti- oxidant66, anti-tumor and many other medicinal67,68 properties.

 

The Pre-Mium Cognitive Blend also stacks three purine alkaloids to ensure clean mental focus: Theacrine (100mg), Caffeine (250mg) and Theobromine(60mg). When it comes to strength and power performance69-74 caffeine isn’t always an effective ergogenic for everyone, all the time71. So, Pre-Mium contains maybe the “cleanest” over-the-counter stimulant of them all: Theacrine (as Teacrine®). Theacrine improves mood, focus, subjective feelings of energy, and motivation to exercise, but actually decreases anxiety. Even after months of daily use (300mg) theacrine does not lose effectiveness or hook you into a nasty habit75 [which may be the case for caffeine71,76]. On the other hand, co-administering theacrine with caffeine may actually prevent de-sensitization77. The Pre- Mium “alkaloid trinity” is topped off by a small dose of theobromine, another mood booster for some individuals78-80 that counterbalances the caffeine’s hypertensive (blood pressure elevating) effect81,82. It’s possible that theobromine may synergize with caffeine to promote arousal83, but reduce perceived exertion during exercise because it’s also a bronchodilator77,84-87. 

 

N-Acetyl L-Tyrosine is Pre-Mium’s soluble source of L-tyrosine88-90, a precursor for catecholamine synthesis (e.g., noradrenaline and dopamine)91- 93, thus supporting brain neurotransmitter levels94 to improve cognitive performance95,96. For instance, in lab animals put under stress, tyrosine normalizes feeding and activity behavior94,97. In stressed “gym animals” (again, that’s you), tyrosine may actually promote the aggressive mentality98 needed to push past performance barriers.

Whats the recommend dosage for PRE-MIUM?

See product labeling for details on dosage.

WARNING

KEEP OUT OF THE REACH OF CHILDREN. Store at room temperature, tightly closed. Avoid excessive heat. Some product clumping may occur. See product labeling for more warning details.

 

Disclaimer: Responses to alkaloid stimulants are variable79,99. L-Tyrosine may interact with certain drugs (such as MAOIs, Levodopa and thyroid medications). 

 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Research and References

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7. Clarkson PM, Hubal MJ. Exercise-induced muscle damage in humans. Am J Phys Med Rehabil. 2002;81(11 Suppl):S52-69.

 

8. Orozco-Gutierrez JJ, Castillo-Martinez L, Orea-Tejeda A, et al. Effect of L- arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction. Cardiol J. 2010;17(6):612-618.

 

9. Sureda A, Cordova A, Ferrer MD, et al. Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise. Free Radic Res. 2009;43(9):828-835.

 

10. van Wijck K, Wijnands KA, Meesters DM, et al. L-citrulline Improves Splanchnic Perfusion and Reduces Gut Injury during Exercise. Med Sci Sports Exerc. 2014.

 

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